Thursday, April 11, 2013

Key pathway to stop dangerous, out-of-control inflammation discovered

Wednesday, April 10, 2013

A potential new strategy to developing new drugs to control inflammation without serious side effects has been found by Georgia State University researchers and international colleagues.

Jian-Dong Li, director of Georgia State's Center for Inflammation, Immunity and Infection, and his team discovered that blocking a certain pathway involved in the biological process of inflammation will suppress it.

Inhibiting a molecule called phosphodiesterase 4B, or PDE4B, suppresses inflammation by affecting a key gene called CLYD, a gene that serves as a brake on inflammation.

The research was published in the journal Nature Communications.

Li explained the process of overactive inflammation using a "police" analogy.

When a pathogen ? such as bacteria or viruses -- infects a patient, he said, it triggers an "alarm" to which the "police" of immune system respond. In turn, it triggers neutrophil attractant called cytokines to respond, leading to inflammation that serves to help rid the body of the pathogen. But if inflammation isn't stopped, tissue damage can result.

The pathways during the response are termed "positive," like a gas pedal on a car, and "negative," like a brake, with the process in the positive pathway going down the line from the pathogen to inflammation, and negative going the other direction. PDE4B is involved in controlling the negative pathway.

Many researchers have been focusing on developing anti-inflammatory agents by stopping the positive pathway, but the discovery by Li and his colleagues gives scientists a new route to stop inflammation using safer or even existing drugs proven to be non-toxic as they have found that accelerating the negative pathway will reduce inflammation.

"This is the key negative regulator that we have been searching after for years, " Li said.

There is a need for better drugs to control inflammation, because current treatments come with serious side effects, Li said. Steroids are commonly used, but cannot be used over the long-term. Steroids suppress the immune system.

###

Georgia State University: http://www.gsu.edu

Thanks to Georgia State University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 58 time(s).

Source: http://www.labspaces.net/127677/Key_pathway_to_stop_dangerous__out_of_control_inflammation_discovered

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Air Force begins grounding combat aircraft

(AP) ? The Air Force began grounding about one-third of its active-duty combat aircraft on Tuesday because of automatic federal spending cuts, including squadrons of fighters, bombers and airborne warning and control craft.

The stand down will affect units stationed in the U.S., Europe and the Pacific, though the Air Force didn't immediately provide a list of the units and bases that will be affected.

Some units that include F-16s, F-22s, A-10s and B-1s will stand down after they return home from their deployments. Other units began the stand down Tuesday.

"We must implement a tiered readiness concept where only the units preparing to deploy in support of major operations like Afghanistan are fully mission capable," Gen. Mike Hostage, commander of Air Combat Command at Joint Base Langley-Eustis, said in a statement. "Units will stand down on a rotating basis so our limited resources can be focused on fulfilling critical missions."

The Air Force says the stand-down is the result of cuts to the command's operations and maintenance account. The Air Force says it must reduce its flying by about 45,000 fewer training hours by Oct. 1 than previously scheduled.

"The current situation means we're accepting the risk that combat airpower may not be ready to respond immediately to new contingencies as they occur," Hostage said.

The Air Force says it generally takes 60 to 90 days to conduct the training needed to return aircrews to mission-ready status. For affected units, the Air Force says it will shift its focus to ground training.

That includes the use of flight simulators and academic training to maintain basic skills and aircraft knowledge, Air Combat Command spokesman Maj. Brandon Lingle said.

Lingle said aircraft maintainers would clear up as much of a backlog of scheduled inspections and maintenance that budgets allow.

___

Brock Vergakis can be reached at www.twitter.com/BrockVergakis

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-04-09-US-Air-Force-Groundings/id-321f24dbd15746649987cd32f01287eb

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1-2 punch could be key in treating blindness

Tuesday, April 9, 2013

Researchers have discovered that using two kinds of therapy in tandem may be a knockout combo against inherited disorders that cause blindness. While their study focused on man's best friend, the treatment could help restore vision in people, too.

Published in the journal Molecular Therapy, the study builds on earlier work by Michigan State University veterinary ophthalmologist Andr?s Kom?romy and colleagues. In 2010, they restored day vision in dogs suffering from achromatopsia, an inherited form of total color blindness, by replacing the mutant gene associated with the condition.

While that treatment was effective for most younger dogs, it didn't work for canines older than 1 year. Kom?romy began to wonder if the older dogs' cones ? the photoreceptor cells in the retina that process daylight and color ? might be too worn out.

"Gene therapy only works if the nonfunctional cell that is primarily affected by the disease is not too degenerated," he said. "That's how we came up with the idea for this new study. How about if we selectively destroy the light-sensitive part of the cones and let it grow back before performing gene therapy? Then you'd have a younger, less degenerated cell that may be more responsive to therapy."

So, Kom?romy and colleagues recruited more dogs with achromatopsia between 1 and 3 years old. To test their theory, they again performed gene therapy but first gave some of the dogs a dose of a protein called CNTF, which the central nervous system produces to keep cells healthy. At a high enough dose, its effect on photoreceptors is a bit like pruning flowers: It partially destroys them, but allows for new growth.

"It was a long shot," said Kom?romy, associate professor in MSU's Department of Small Animal Clinical Sciences.

But it worked.

"We were just amazed at what we found," he said. "All seven dogs that got the combination treatment responded, regardless of age."

While achromatopsia is quite rare, Kom?romy said it's a good model disease for other disorders affecting the photoreceptors, conditions that constitute a major cause of incurable blindness in dogs and humans. Those disorders affect individuals of both species in much the same way, so the combination treatment's promise isn't just for Fido.

"Based on our results we are proposing a new concept of retinal therapy," he said. "One treatment option alone might not be enough to reverse vision loss, but a combination therapy can maximize therapeutic success."

###

Michigan State University: http://www.newsroom.msu.edu

Thanks to Michigan State University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 42 time(s).

Source: http://www.labspaces.net/127657/____punch_could_be_key_in_treating_blindness

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How 'burps' help forecast volcanic eruptions

J. Kauahikaua / USGS

Volcanic gasses and ash emanate from the summit eruptive vent as a vast plume, and from surrounding fumaroles at Kilauea Volcano on 28 May 2009. The vent, which formed in March 2008, broke a 26-year-long period of no eruptive activity at Kilauea's summit.

By Becky Oskin
LiveScience

It's rarely good news when a volcano has indigestion. Volcanic gas "burping" from a fiery peak signals magma moving down below ? a warning sign of a possible eruption.

If scientists can reach hazardous volcanoes ? such as at Hawaii's Kilauea volcano ? on foot or by helicopter, they collect samples to track the volcanoes? gas emissions. Now, a new study of Kilauea's 2008 summit eruption reveals simple earthquake monitors can perform a similar task. The results appear in Tuesday's?issue of the journal Nature Communications.

"This is another tool to forecast eruptions, particularly on remote islands, where gas monitoring is not possible," said Jessica Johnson, lead author of the study and a geophysicist at the U.S. Geological Survey's (USGS) Hawaii Volcano Observatory.

Johnson and USGS colleague Michael Poland tested the idea at Kilauea's Halema'uma'u crater. On March 19, 2008, gas and lava punched through the crater wall, birthing a new lava lake. Before the eruption, sulfur-dioxide gas levels jumped, and so did the number of earthquakes. Thanks to these clues, scientists knew magma was churning, but the actual eruption's exact timing was still a surprise.

Johnson went back to the 2008 records from Kilauea's seismometers, instruments that record earthquakes, and examined how the seismic waves traveled through different underground rock layers. Earthquake waves can split ? similar to the way light passes through polarized sunglasses ? and they'll travel faster along layers than across layers, Johnson explained. Cracks in the rock layers can also change this "polarization" as the voids open and close in response to changing forces, such as Kilauea's growing and ebbing magma chambers. [Amazing Images from Kilauea's Lava Lake]

J. Kauahikaua / USGS

Tourists pose for photos on Sept. 26, 2009 not far from the ongoing eruptive vent inside Halema`uma`u crater that spews a dark plume of gas and ash into the atmosphere above Kilauea Volcano in Hawaii.

Before the 2008 Kilauea eruption, an increasing amount of gas forced its way through fissures and cracks in the volcano's summit lava flows, and the changing stress affected how earthquake waves traveled through the rock layers, Johnson discovered. ?Johnson looked at the changes in the earthquake waves, a technique called earthquake "shear wave splitting," and was able to link them to the rising gas levels, something that has never before been done at Kilauea.

Johnson also has tested the technique at New Zealand's Rotorua and Tongariro volcanoes, where she saw hints of Tongariro's imminent 2012 eruption. Had the earthquake-gas monitoring been used before Kilauea's 2008 eruption, it wouldn't have tipped the scales toward predicting the eruption, especially since Kilauea is already so heavily monitored, Johnson said. But the setup could come in handy at remote volcanoes, such as those on Alaska's Aleutian Islands, where regular gas monitoring is impracticable or impossible.

With four seismometers (at least one must measure in three directions: up-down, east-west and north-south), scientists could detect rising gas levels, Johnson said. Such setups are already in place at many active volcanoes worldwide, she added.

"At a volcano where you don't have gas measurements, this would give you enormous additional information," Johnson told OurAmazingPlanet.

Email Becky Oskin or follow her @beckyoskin. Follow us?@OAPlanet, Facebook?or Google+. Original article on LiveScience's OurAmazingPlanet.

Copyright 2013 LiveScience, a TechMediaNetwork company. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2a86e3c9/l/0Lscience0Bnbcnews0N0C0Inews0C20A130C0A40C0A90C17675250A0Ehow0Eburps0Ehelp0Eforecast0Evolcanic0Eeruptions0Dlite/story01.htm

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Rick Santorum: Gay Marriage Support "Suicidal" For GOP

Source: http://www.thehollywoodgossip.com/2013/04/rick-santorum-gay-marriage-support-suicidal-for-gop/

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Wednesday, April 10, 2013

Was McConnell's Staff Dirt-Digging on Ashley Judd? (ABC News)

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Remains of the Day: The Google Play Store Gets a Redesign

Remains of the Day: The Google Play Store Gets a RedesignThe Google Play Store gets a design refresh, AT&T customers get free Wi-Fi in some international airports, Microsoft prepares to roll out two-factor authentication, and Chrome for iOS gets an update.

Photo by photastic (Shutterstock), a2bb5s (Shutterstock), and Feng Yu (Shutterstock).

Source: http://feeds.gawker.com/~r/lifehacker/full/~3/jLN8lAynAUk/remains-of-the-day-the-google-play-store-gets-a-redesign

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Calif. prisons need better mental health care: judge

By Sharon Bernstein

LOS ANGELES (Reuters) - A federal judge has rebuffed California Governor Jerry Brown's effort to ease U.S. oversight of mental health services in the state's overcrowded prisons, saying he did not trust officials to improve conditions for inmates.

Brown, a Democrat, is under political pressure to scale back a program under which state prisoners are sent to local jurisdictions to ease crowding. That move has led to the early release of thousands of non-violent offenders from lower-level county jails as municipalities struggle to make room for them.

California has been under court orders to reduce population in the 33-prison system since 2009, when a panel of federal judges ordered it to relieve the overcrowding that has caused inadequate medical and mental health care.

California must reduce its prison population to 137.5 percent of capacity by June 27. The Department of Corrections and Rehabilitation reported 119,213 inmates on January 2, just under 150 percent of capacity.

In January, Brown asked a panel of federal judges to vacate its order to further lower its prison population, saying that California had fixed its overcrowding problem and further releases of prisoners would harm public safety.

"In the years since the court issued the current population cap order, the state has dramatically reduced the prison population, significantly increased capacity through construction, and implemented a myriad of improvements that transformed the medical and mental health care systems," the Brown administration said in court filings.

On Friday, U.S. District Court Judge Lawrence K. Karlton, whose court is in Sacramento, denied in a 68-page opinion the administration's request to be released from federal oversight of an order to improve mental health care for inmates.

A further ruling, on the state's assertion that it should not be required to reduce its prison population to 137.5 percent of capacity by June, is expected in the coming months.

"Overcrowding in California's prison system was the primary cause of the state's failure to remedy ongoing constitutional violations in the delivery of mental health care to prison inmates," Karlton wrote.

He added that, despite arguments that the system had improved, there were not enough beds to house mentally ill inmates, nor enough staff members to treat them.

He expressed skepticism that California, if released from the oversight of the court, would follow through on promises to improve conditions.

"Based on defendants' conduct to date, the court cannot rely on their averments of good faith," Karlton wrote.

He also criticized the administration for failing to provide adequate mental health supports for inmates, citing "systemic failures" in suicide prevention and other care for mentally ill inmates.

(Editing by Cynthia Johnston and Lisa Shumaker)

(This story was corrected to show ruling addresses mental health services for inmates in overcrowded prisons rather than overcrowding itself and adds comment from judge to show link between the two issues in headline, paragraphs 1, 7-9)

Source: http://news.yahoo.com/crowded-california-prisons-fall-short-mental-health-care-234633738.html

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Sudan's army says kills 15 rebels, retakes part of South Darfur

CAIRO (Reuters) - Sudanese forces retook a southern part of the country's Darfur region after clashing with insurgents, killing 15, a military spokesman said on Tuesday, while rebels claimed victory in fighting in northern Darfur.

Spokesman Al-Sawarmi Khalid Saad said the army had repulsed an attack by rebels loyal to veteran fighter Minni Minawi on the Dubu area in South Darfur state, and the state news agency SUNA said government forces had reasserted control over the area.

Separately, a spokesman for the Sudan Liberation Army (SLA) faction led by Abdel Wahed Mohamed al-Nur told Reuters that rebels had stormed and seized three military camps in North Darfur state, killing 64 soldiers.

Events in Darfur are hard to independently verify because of restrictions on media access to the region.

Conflict has torn Darfur since 2003 when mainly non-Arab rebels took up arms against the Arab-led government, accusing it of politically and economically marginalizing the region.

Violence has subsided from its peak in 2003 and 2004, but a surge has forced more than 130,000 people to flee their homes since the start of this year, according to the United Nations.

In 2008, the United Nations said about 300,000 people may have died in Darfur's war, a figure some activists said was too low. The Khartoum government has put the death toll at about 10,000.

(Writing by Maggie Fick; Editing by Mark Heinrich)

Source: http://news.yahoo.com/sudans-army-says-kills-15-rebels-retakes-part-185031921.html

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Internet Marketing: Where to begin?


Hello everyone. I am new to this site and internet marketing in general. The information available here all seems like great material, but it all seems specific to certain techniques or strategies.

What would be the best marketing strategies with which to start for a person new to this process?

I have read about cost-per-action ads, pay-per-download, pay-per-click, and others. They seem to do well in each of their regards; but, where would one go to find the best markets to apply these techniques?

I am really not sure to what niche I would be selling, and that is where I am stuck. So what I am most curious is where to find any information or stats describing the best performing markets or niches to sell.

I do have hosting available to use and have tinkered with WordPress and other CPM templates, so I will probably be using this approach unless there are reasons to avoid this.

I would like to set myself to a moderate goal. Would $10 a day be too far fetched?

Any help would be appreciated.

P.S. I am not sure if this is the right forum to post into with this inquiry, but it seemed the most general for "Making Money".

Source: http://www.blackhatworld.com/blackhat-seo/making-money/552986-internet-marketing-where-begin.html

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Tuesday, April 9, 2013

Just us (Powerlineblog)

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Senate confirms White to head SEC

WASHINGTON (AP) ? The U.S. Senate has confirmed Mary Jo White's nomination as chairman of the Securities and Exchange Commission, making her the first former prosecutor to lead the federal agency that oversees Wall Street.

White was approved Monday by a Senate voice vote. She will replace Elisse Walter, who has been interim SEC chairman since Mary Schapiro resigned in December.

President Barack Obama nominated White, who had served as U.S. attorney in Manhattan from 1993 through 2002.

Critics have complained that the SEC has failed to act aggressively to charge top executives at the biggest U.S. banks who may have contributed to the crisis that set off the Great Recession.

White told the Senate Banking Committee last month that she would aggressively pursue enforcement and hold accountable "all wrongdoers ? individual and institutional, of whatever position or size."

As SEC chairman, she will also lead efforts to complete and enforce complex regulations called for by Congress in response to the 2008 financial crisis.

White, 65, was the first woman to be named U.S. attorney in Manhattan, one of the most prestigious jobs in law enforcement. During her tenure, she built an extensive record of prosecuting white-collar crime, won convictions in the 1993 World Trade Center bombing and the 1998 terrorist attacks on two U.S. embassies in Africa, and put crime boss John Gotti away.

She left the U.S. attorney's office in 2002 and went to work for Debevoise & Plimpton, where she served as head of litigation for the prominent New York law firm. Her clients included JPMorgan Chase, Microsoft, General Electric and Toyota, and former Bank of America CEO Ken Lewis.

During her confirmation hearing, White pledged to avoid potential conflicts of interest from that work. She also promised in writing to step aside as SEC chairman from any decision affecting a former client for one year after she represented them. That's in line with federal ethics guidelines for agency officials. The same pledge has been made by a number of SEC chairmen, many of whom were formerly private securities lawyers.

The SEC chairman and commissioners must vote to approve enforcement actions against specific companies or individuals as well as new rules that apply generally.

"The American public will be my client, and I will work as zealously as possible on behalf of them," White told the Senate Banking Committee.

In addition, White has pledged to abstain from all decisions before the SEC brought by the law firm of her husband, John White, who is a corporate attorney and a former high-ranking SEC official.

Source: http://news.yahoo.com/senate-confirms-white-head-sec-185846756--finance.html

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Dem, GOP senators work on background check deal (The Arizona Republic)

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Widely used filtering material adds arsenic to beers

Apr. 7, 2013 ? The mystery of how arsenic levels in beer sold in Germany could be higher than in the water or other ingredients used to brew the beer has been solved, scientists announced in New Orleans April 7 at the 245th National Meeting & Exposition of the American Chemical Society.

Mehmet Coelhan, Ph.D., and colleagues said the discovery could be of importance for breweries and other food processors elsewhere that use the same filtering technology implicated in the elevated arsenic levels in some German beers. Coelhan's team at the Technische Universit?t in Munich set out to solve that riddle after testing 140 samples of beers sold in Germany as part of a monitoring program. The monitoring checked levels of heavy metals like arsenic and lead, as well as natural toxins that can contaminate grain used in brewing beer, pesticides and other undesirable substances.

Coelhan explained that the World Health Organization uses 10 micrograms per liter of arsenic in drinking water as a limit. However, some beers contained higher arsenic levels. "When arsenic level in beer is higher than in the water used during brewing, this excess arsenic must come from other sources," Coelhan noted. "That was a mystery to us. As a consequence, we analyzed all materials, including the malt and the hops used during brewing for the presence of arsenic."

They concluded that the arsenic was released into the beer from a filtering material called kieselguhr, or diatomaceous earth, used to remove yeast, hops and other particles and give the beer a crystal clear appearance. Diatomaceous earth consists of fossilized remains of diatoms, a type of hard-shelled algae that lived millions of years ago. It finds wide use in filtering beer, wine and is an ingredient in other products.

"We concluded that kieselguhr may be a significant source of arsenic contamination in beer," Coelhan said. "This conclusion was supported by analysis of kieselguhr samples. These tests revealed that some kieselguhr samples release arsenic. The resulting arsenic levels were only slightly elevated, and it is not likely that people would get sick from drinking beers made with this filtration method because of the arsenic. The arsenic is still at low levels -- the risk of alcohol poisoning is a far more realistic concern, as stated in previous studies on the topic."

Coelhan pointed out that beers produced in at least six other countries had higher arsenic amounts than German beers, according to a report published four years ago. He said that breweries, wineries and other food processors that use kieselguhr should be aware that the substance can release arsenic. Substitutes for kieselguhr are available, he noted, and simple measures like washing kieselguhr with water can remove the arsenic before use.

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Broadcasters worry about 'Zero TV' homes

LOS ANGELES (AP) ? Some people have had it with TV. They've had enough of the 100-plus channel universe. They don't like timing their lives around network show schedules. They're tired of $100-plus monthly bills.

A growing number of them have stopped paying for cable and satellite TV service, and don't even use an antenna to get free signals over the air. These people are watching shows and movies on the Internet, sometimes via cellphone connections. Last month, the Nielsen Co. started labeling people in this group "Zero TV" households, because they fall outside the traditional definition of a TV home. There are 5 million of these residences in the U.S., up from 2 million in 2007.

Winning back the Zero TV crowd will be one of the many issues broadcasters discuss at their national meeting, called the NAB Show, taking place this week in Las Vegas.

While show creators and networks make money from this group's viewing habits through deals with online video providers and from advertising on their own websites and apps, broadcasters only get paid when they relay such programming in traditional ways. Unless broadcasters can adapt to modern platforms, their revenue from Zero TV viewers will be zero.

"Getting broadcast programing on all the gizmos and gadgets ? like tablets, the backseats of cars, and laptops ? is hugely important," says Dennis Wharton, a spokesman for the National Association of Broadcasters.

Although Wharton says more than 130 TV stations in the U.S. are broadcasting live TV signals to mobile devices, few people have the tools to receive them. Most cellphones require an add-on device known as a dongle, but these gadgets are just starting to be sold.

Among this elusive group of consumers is Jeremy Carsen Young, a graphic designer, who is done with traditional TV. Young has a working antenna sitting unplugged on his back porch in Roanoke, Va., and he refuses to put it on the roof.

"I don't think we'd use it enough to justify having a big eyesore on the house," the 30-year-old says.

Online video subscriptions from Netflix Inc. and Amazon.com Inc. ? which cost less than $15 a month combined ? have given him and his partner plenty to watch. They take in back episodes of AMC's "The Walking Dead" and The CW's "Supernatural," and they don't need more, he says.

He doesn't mind waiting as long as a year for the current season's episodes to appear on streaming services, even if his friends accidently blurt out spoilers in the meantime. With regular television, he might have missed the latest developments, anyway.

"By the time it gets to me to watch, I've kind of forgotten about that," he says.

For the first time, TV ratings giant Nielsen took a close look at this category of viewer in its quarterly video report released in March. It plans to measure their viewing of new TV shows starting this fall, with an eye toward incorporating the results in the formula used to calculate ad rates.

"Our commitment is to being able to measure the content wherever it is," says Dounia Turrill, Nielsen's senior vice president of insights.

The Zero TV segment is increasingly important, because the number of people signing up for traditional TV service has slowed to a standstill in the U.S.

Last year, the cable, satellite and telecoms providers added just 46,000 video customers collectively, according to research firm SNL Kagan. That's tiny when compared to the 974,000 new households created last year. While it's still 100.4 million homes, or 84.7 percent of all households, it's down from the peak of 87.3 percent in early 2010.

Nielsen's study suggests that this new group may have left traditional TV for good. While three-quarters actually have a physical TV set, only 18 percent are interested in hooking it up through a traditional pay TV subscription.

Zero TVers tend to be younger, single and without children. Nielsen's senior vice president of insights, Dounia Turrill, says part of the new monitoring regime is meant to help determine whether they'll change their behavior over time. "As these homes change life stage, what will happen to them?"

Cynthia Phelps, a 43-year-old maker of mental health apps in San Antonio, Texas, says there's nothing that will bring her back to traditional TV. She's watched TV in the past, of course, but for most of the last 10 years she's done without it.

She finds a lot of programs online to watch on her laptop for free ? like the TED talks educational series ? and every few months she gets together with friends to watch older TV shows on DVD, usually "something totally geeky," like NBC's "Chuck."

The 24-hour news channels make her anxious or depressed, and buzz about the latest hot TV shows like "Mad Men" doesn't make her feel like she's missing out. She didn't know who the Kardashian family was until she looked them up a few years ago.

"I feel absolutely no social pressure to keep up with the Joneses in that respect," she says.

For Phelps, it's less about saving money than choice. She says she'd rather spend her time productively and not get "sucked into" shows she'll regret later.

"I don't want someone else dictating the media I get every day," she says. "I want to be in charge of it. When I have a TV, I'm less in control of that."

The TV industry has a host of buzz words to describe these non-traditionalist viewers. There are "cord-cutters," who stop paying for TV completely, and make do with online video and sometimes an antenna. There are "cord-shavers," who reduce the number of channels they subscribe to, or the number of rooms pay TV is in, to save money.

Then there are the "cord-nevers," young people who move out on their own and never set up a landline phone connection or a TV subscription. They usually make do with a broadband Internet connection, a computer, a cellphone and possibly a TV set that is not hooked up the traditional way.

That's the label given to the group by Richard Schneider, the president and founder of the online retailer Antennas Direct. The site is doing great business selling antennas capable of accepting free digital signals since the nation's transition to digital over-the-air broadcasts in 2009, and is on pace to sell nearly 600,000 units this year, up from a few dozen when it started in 2003.

While the "cord-nevers" are a target market for him, the category is also troubling. More people are raised with the power of the Internet in their pocket, and don't know or care that you can pull TV signals from the air for free.

"They're more aware of Netflix than they're aware over-the-air is even available," Schneider says.

That brings us to truck driver James Weitze. The 31-year-old satisfies his video fix with an iPhone. He often sleeps in his truck, and has no apartment. To be sure, he's an extreme case doesn't fit into Nielsen's definition of a household in the first place. But he's watching Netflix enough to keep up with shows like "Weeds," ''30 Rock," ''Arrested Development," ''Breaking Bad," ''It's Always Sunny in Philadelphia" and "Sons of Anarchy."

He's not opposed to TV per se, and misses some ESPN sports programs like the "X Games."

But he's so divorced from the traditional TV ecosystem it could be hard to go back. It's become easier for him to navigate his smartphone than to figure out how to use a TV set-top box and the button-laden remote control.

"I'm pretty tech savvy, but the TV industry with the cable and the television and the boxes, you don't know how to use their equipment," he says. "I try to go over to my grandma's place and teach her how to do it. I can't even figure it out myself."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/495d344a0d10421e9baa8ee77029cfbd/Article_2013-04-07-Zero%20TV/id-47d74595ad4d42f2a13411916ce65756

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Kerry to Turkey: Mend ties with Israel quickly

ISTANBUL (AP) ? U.S. Secretary of State John Kerry on Sunday urged Turkey's leaders to quickly restore full diplomatic relations with Israel, but Turkey demanded that Israel first end all "embargoes" against the Palestinians.

The Obama administration sees the two U.S. allies as anchors of stability in a Middle East amid Syria's civil war, Arab Spring political upheavals and the threat posed by Iran's nuclear program.

In Istanbul on the first leg of a 10-day overseas trip, Kerry met with Foreign Minister Ahmet Davutoglu with the aim of firming up the rapprochement between Turkey and Israel that President Barack Obama revived during a visit to Israel state last month.

Kerry met later with Prime Minister Recep Tayyip Erdogan before traveling on to Israel.

"We would like to see this relationship that is important to stability in the Middle East and critical to the peace process ... get back on track in its full measure," Kerry told reporters at a news conference with Davutoglu. He said that meant promises of "compensation be fulfilled, ambassadors be returned and that full relationship be embraced."

Turkey and Israel were once close partners, but the relationship plummeted in 2010 after an Israeli raid on a flotilla bound for the Gaza Strip. Eight Turks and a Turkish-American died.

Before leaving Israel two weeks ago, Obama arranged a telephone conversation between Israeli Prime Minister Benjamin Netanyahu and Erdogan. Netanyahu apologized for the incident; compensation talks are expected to begin this week.

But Davutoglu suggested that full normalization of ties would probably take some time.

"There is an offense that has been committed and there needs to be accountability," Davutoglu said. He signaled that Turkey would pursue a "careful" advance toward a complete restoration of relations, with compensation and an end to Israeli trade restrictions on the Gaza Strip as the stumbling blocks.

"All of the embargoes should be eliminated once and for all," he said through an interpreter.

Fixing the relationship has been a long-sought goal of the Obama administration, and the U.S. desperately wants significant progress by the time Erdogan visits the White House in mid-May.

The Turks have reveled somewhat in what they view as a diplomatic victory, with billboards in Ankara celebrating Netanyahu's apology and praising Erdogan for bringing pride to his country.

Perhaps seeking to add to his leverage, Erdogan signaled shortly after the call that he was in no hurry to finalize the deal and pledged to visit the Hamas-controlled Palestinian territory soon.

From a U.S. strategic sense, cooperation between the American allies has only become more important as Syria's 2-year conflict has grown ever deadlier.

More than 70,000 people have died in the war, according to the United Nations, but the U.S. fears it could get even worse ? by spilling into neighboring countries or through chemical weapons being used. Both potential scenarios have prompted intense contingency planning among Washington and its regional partners, Israel and Turkey included.

Kerry, who noted his twice-weekly telephone chats with Davutoglu, spoke of shared U.S. and Turkish efforts to support Syria's opposition coalition.

The opposition has suffered from poor coordination between its political leadership and the military factions leading the fight against the Assad regime, and from intense infighting among those who seek to guide the amorphous movement's overall strategy.

Turkey has gone further than the U.S. in its assistance, accepting some 180,000 Syrians as refugees and sending advanced weaponry to rebels fighting to overthrow Syrian President Bashar Assad.

The U.S. is only providing nonlethal aid to the rebels in the form of meals, medical kits and training.

Kerry praised Turkey for its generosity toward refugees and commitment to keeping its borders open, an issue of growing U.S. concern as the outflow of Syrians stretches the capacities of neighboring countries to accommodate them.

"The United States and Turkey will continue cooperating toward the shared goal of a peaceful transition in Syria," he said.

A U.S. official stressed ahead of Kerry's meetings that he would also urge the Turks to be cautious about the contentious issue of Iraqi oil.

Turkey wants to import oil directly from Iraq's autonomous Kurds in the north, a step that would enrage the central government in Baghdad and one the U.S. opposes. Washington doesn't want the riches of Iraq to bring the country back to sectarian warfare and has urged that any export arrangement get the Iraqi government's blessing.

From Turkey, Kerry headed to Israel, his third trip there in the span of two weeks.

He planned to meet Palestinian President Mahmoud Abbas in Ramallah on Sunday night, followed by Netanyahu and other senior Israeli and Palestinian officials Monday as part of a fresh American bid to unlock the long-stalled Middle East peace process.

Conversations in Israel will also cover shared U.S. and Israeli concerns over Iran's nuclear program.

The U.S. and other world powers met the Islamic republic in Kazakhstan for another round of negotiations, but no breakthrough was announced on a proposed deal that would see international penalties eased on Iran if Tehran convinces the world that it is not trying to develop nuclear weapons.

Kerry said the "door is still open" for a negotiated agreement, but that the onus was on the Iranians.

"If you have a peaceful program for nuclear power, as a number of nations do, it's not hard to prove that," he said. "They have chosen not to live up to the international requirements and standards with respect to verification of their program."

The other stops on his trip are Britain, South Korea, China and Japan. He returns to Washington on April 15.

Source: http://news.yahoo.com/kerry-turkey-mend-ties-israel-quickly-162205832--politics.html

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Monday, April 8, 2013

Drew Barrymore: Woman Cannot Have It All

Source: http://www.thehollywoodgossip.com/2013/04/drew-barrymore-woman-cannot-have-it-all/

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Climate Change Could Equal Teeth-Rattling Flights

AFP/Getty Images

Fly the bumpier skies?

AFP/Getty Images

Buckle up ? climate change could make this a bumpy flight.

That's according to a newly published study by two British scientists who say increased levels of CO2 in the atmosphere will make "clear air turbulence" ? which can't be easily spotted by pilots or satellites ? more common over the North Atlantic. That means the potential for gut-wrenching flights between the U.S., Europe and points east.

According to Scientific American, researchers Paul D. Williams and Manoj M. Joshi, "used computer simulations to fast-forward to the year 2050. They fed that future climate data to 21 turbulence-predicting algorithms."

According to the BBC:

"The modelling suggested the average strength of transatlantic turbulence could increase by between 10% and 40%, and the amount of airspace likely to contain significant turbulence by between 40% and 170%, where the most likely outcome is around 100%. In other words, a doubling of the amount of airspace affected.

" 'The probability of moderate or greater turbulence increases by 10.8%,' said Dr Williams."

The possible consequences go beyond mere passenger discomfort and could well show up on the bottom line for airlines, Williams tells the BBC.

"It's certainly plausible that if flights get diverted more to fly around turbulence rather than through it then the amount of fuel that needs to be burnt will increase," Williams says. "Fuel costs money, which airlines have to pay, and ultimately it could of course be passengers buying their tickets who see the prices go up."

Some 600 flights crisscross the North Atlantic corridor each day, according to the BBC reports.

Source: http://www.npr.org/blogs/thetwo-way/2013/04/08/176598063/climate-change-could-equal-teeth-rattling-flights?ft=1&f=1007

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You Can Try a Leaked, Janky Version of Facebook Home Right Now

Facebook home won't charge into the Google Play store in all its launcher-replacement glory until April 12. But if you need to see it right now, you can satiate your sick urge with a pre-release leak unearthed by Modaco. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/KIHg-3he-YU/you-can-try-a-leaked-janky-version-of-facebook-home-right-now

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Michael Bloomberg needs more thorough background check system for his ?Mayors Against Illegal Guns? (Michellemalkin)

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Monarch High senior sheds locks for cancer research

Jon Ansell sits in the center of Monarch High School's gym in front of hundreds of people, and he's about to give up the thick, curly hair he's been growing for eight years.

As the barber drapes him with a cutting cape, Ansell is nothing but smiles, most likely because of the reason he's about top lose his locks.

Ansell shaved his head Friday to help raise money for cancer research, a cause that has touched his life not once but twice.

"My grandpa passed away from cancer," Ansell said. "One of my best friends was diagnosed with leukemia at a really young age, so I've grown up with it."

"But he's still here doing great!" Jon's mom, Jodi Ansell, added with a smile.

The 18-year-old Monarch senior had some time to adjust to the idea of having short hair, which until Friday morning reached just past his shoulders -- both downwards and outwards. According to Jodi Ansell, Monarch social studies teacher Keith Mainland came to Jon Ansell a year ago and asked, "Would you shave your head to raise money for cancer?"

"Sure," he said, "I'll do it."

"I always planned on trying to donate my hair or something like it," Jon Ansell explained. "Mr. Mainland approached me and had the idea to shave it for St. Baldrick's Day. I decided that if I'm shaving it, I might as well try to raise money for cancer research."

Because the haircut didn't fall on the actual St. Baldrick's Day, a nationwide annual event to raise money for a cure for childhood cancer, Jon Ansell pledged to shave his head at a school assembly if he raised $1,000 for American Cancer Society. He ended up with a $1,500 haircut, with more donations coming in from staff and students as the locks fell to the floor.

"I can finally feel the air on my head, which is strange," Jon Ansell said after the cut. It took over 10 minutes to "Mow the 'Fro," as the event was dubbed by the school.

Students gasped and cheered as his familiar Afro turned into a buzzcut. Jon kept his smile the whole time, but Jodi Ansell admitted she teared up as his hair came off.

"Just hearing the audience, I was more wondering what he was thinking when he can't see what's on his head," she said.

Most of the people at Monarch High had likely not seen Jon Ansell with hair so short before Friday. His friend let out a noise of excitement as she walked by in the hallway and ruffled his new cut. He wants to donate the shorn eight-year growth to Locks of Love, which he's been trying to do since he was 10.

"Initially, when he started growing it when he was 10, it was because one of his friends was growing out for Locks of Love, " Jodi Ansell said. "He thought, 'Oh, maybe I'll do that too.' But then it grew out and it was gorgeous." Jon also noted that, "skater hair was big" at the time, both his literal hair and the style itself, so he didn't cut it right away.

Despite the length of time that Jon Ansell grew out his hair, Mainland isn't sure if Locks of Love will take it, because it might not meet the organization's length standards.

"You're kidding!" Jodi Ansell said when Mainland told her.

"Because it's frizzy and out rather than long and straight, [I don't know] whether they can use it," Mainland said.

"See if they can treat it with curl relaxer," Larry Ansell, Jon's father, joked.

Jon Ansell isn't worried about the logistics of donating his hair.

"I think I'll just send it in to Locks of Love, and if they need it, they can take it," he said.

Raising money for cancer research is another activity that Jon Ansell can add to his list of accomplishments, which includes National Honors Society, Key Club, soccer, choir and theater.

"I'm really proud of him," Jodi Ansell said. "I'm in shock" about his hair.

Larry Ansell acknowledged the positive effect this event has had on his son.

"You changed the course of his life," Larry said to Mainland, after the cut.

Jon Ansell will attend the University of Colorado in the fall. Whether the 'fro will be back, or his hair will stay short, the well-rounded teenager should adjust easily to his new haircut and his next chapter.

Source: http://www.dailycamera.com/louisville-news/ci_22966092/monarch-high-senior-sheds-locks-cancer-research?source=rss_viewed

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Sandy Hook families bring emotion to gun debate (The Arizona Republic)

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PFT: Raiders have $45 million in dead money

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As thousands of Davids prepare to take on the sports world?s Goliath in the NFL concussion lawsuits, Goliath has a fairly large stone that he?s about to drop on all of them.

Lost in the sympathy and intrigue generated by 4,200 former pro football players suing the caretakers of the game they played is the fact that the NFL, as it usually does, has some strong legal arguments.? The first one makes its way to Judge Anita Brody?s court in Philadelphia on Tuesday, after the submission of extensive written materials by the lawyers.

The NFL?s threshold position comes from the labor deal.? The league believes that the various Collective Bargaining Agreements negotiated by the players and the league control the situation, and that any claims for failure to protect players from concussions or to disclose to them the risks of concussions should be pursued via the dispute-resolution system created by the CBAs.

?Although the CBAs have changed over time pursuant to the collective bargaining process, every CBA expressly addresses player health and safety and provides grievance procedures for the resolution of disputes,? the league explained in a submission to the court, via the Philadelphia Inquirer.

The former players obviously disagree, but it?s common in situations like this for the employer to argue aggressively and loudly that workers who have banded together to form a union must rely on the less formal system of dispensing justice that the labor agreement creates.? The workers don?t prefer that approach because it removes from the process a jury of lay persons who could be inclined to decide the case based on dynamics other than the law and the facts.

A jury is far more likely to feel sorry for the former players than an arbitrator would.? Likewise, a jury would be much more inclined to resolve doubt in favor of the players, given the perception that the league has more than enough money to pay a verdict.? Throw in the idea that the men who made the game what is it today earned peanuts in comparison to the amounts paid to today?s players and coaches and executives and owners, and it becomes very easy for a jury to sidestep a morass of conflicting scientific contentions and legal arguments and decide to redistribute the wealth based on a visceral notion of fairness.

That?s why the NFL is fighting so hard to push the case from a court of law to arbitration.? And that?s why this initial skirmish in the concussion litigation will have a dramatic impact on the ultimate outcome of the case.

Source: http://profootballtalk.nbcsports.com/2013/04/06/mckenzies-still-a-year-away-from-rebuilding-raiders/related/

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Early-backer GameStick consoles delayed to June release, Dev units now shipping

Fancied PlayJams' GameStick Android gaming console enough to back it on Kickstarter earlier this year? The good news is that Dev units have been shipping to the roughly 600 who signed up, with the remaining ones set to head out within a week. The bad news? The early-backer versions are now set to arrive at doorsteps in late June instead of April because of high-demand, according to PlayJam. As its latest Kickstarter update details, the units will need stronger tooling than the silicon-based molds of the dev units to ensure that "tens of thousands" of them can be successfully made. Additionally, this will apparently force the company to ship these larger factory yields via sea transport rather than air, which also slows things down.

A case of success causing slowdowns it seems. Hopefully not much longer than these new estimates, too -- while this breakout underdog is set to hit retailers like GameStop, that other Android-based console, OUYA, is already shipping out to backers -- and its retail units are planned in June. You'll find the full update from PlayJam at the source link.

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Source: PlayJam (Kickstarter)

Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/Q9oLt2oojPA/

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